Journal: Scientific Reports
Article Title: Autophagy and ubiquitin-dependent proteolysis processes in left ventricular mass loss in pulmonary arterial hypertension
doi: 10.1038/s41598-024-64950-4
Figure Lengend Snippet: Box and whisker plots comparing plasma levels of ( A ) NT-proBNP, ( B ) SERPINA3, ( C ) Endothelin-1 and ( D ) Interleukin-6 in early PAH, end-stage PAH and matched controls. Data are presented as mean ± SD, n = 8 per group. Statistical analyses were performed using a t-test or Mann–Whitney test depending on the normality of the distributions. Control 1—control rats time-paired with early PAH animals, control 2—control rats rats time-paired with end-stage PAH animals.
Article Snippet: Endothelin-1, a key mediator in the pathogenesis of PAH (Endothelin-1 Quantikine ELISA Kit, Bio-Techne, US) Interleukin-6, an inflammatory cytokine that promotes the development and progression of pulmonary vascular remodeling and heart failure (Rat Interleukin-6 ELISA Kit, Sigma, Germany)
Techniques: Whisker Assay, MANN-WHITNEY, Control